doc. RNDr. Martin Falk, Ph.D.

Curriculum Vitae

Person-Related Identification Information

• RNDr. Martin Falk, PhD.
  Born 14th May 1976 in Teplice, Czech Republic
  UČO 9835
  Phone: +420-5-41517165, +420-728-084060
  e-mail: mfalk@seznam.cz falk@ibp.cz
  https://is.muni.cz/auth/osoba/9835?lang=cs#cv
  

Affiliation

• Institute of Biophysics of ASCR
  Královopolská 135
  612 65 Brno
  Czech Republic
  URL: http://www.ibp.cz
  

Employment - Position

• Head, Department of Cell Biology & Radiobiology

Education and Academic Qualifications

• 2018: Special state exam, title: Radiation Protection Officer and Qualified Expert at the field of radiation protection at workplaces with important sources of ionizing radiation
• 2008: Special state exam, title: Radiation Protection Officer and Qualified Expert at the field of radiation protection at workplaces with important sources of ionizing radiation
• 2004: Ph.D. degree in Molecular and Cell Biology, title Ph.D., thesis: “Hypotheses on the relationship between higher-order chromatin structure and gene expression”, Faculty of Sciences, Masaryk University, Brno, Czech Republic
• 2003: Doctor degree in Molecular Biology and Genetics, title RNDr. (Rerum Naturalis Doctor), thesis: Methodological Possibilities of Determination of the CTG/CAG-unit number in trinucleotide repeats of the Human Genome, Faculty of Sciences, Masaryk University, Brno, Czech Republic
• 2000: graduate degree in Molecular Biology and Genetics, title Mgr. (Magister), diploma thesis: "Pathological Statuses Following from Trinucleotide Expansions. Molecular Diagnostics of Myotonic Dystrophy", Faculty of Sciences, Masaryk University, Brno, Czech Republic and Laboratory of Molecular Genetics, Dept. of Medical Genetics, Faculty Hospital Brno, Czech Republic
• 1998: bachelor degree in Molecular Biology and Genetics, title Bc. (Bachelor), Faculty of Sciences, Masaryk University, Brno, Czech Republic
• 1995: secondary school-leaving exam, Gymnasium J. A. Komenský, Dubí, Czech Republic

Employment

• 2014-now: Institute of Biophysics of ASCR Brno, Head, Department of Cell Biology & Radiobiology
• 2011-now: Institute of Biophysics of ASCR Brno, Head, Laboratory of Chromatin Function, Damage and Repair“
• 2009-2012: Faculty Hospital Brno, Institute of Pathology, Principal Investigator of the grant project (part time employment)
• 2007-2010: Institute of Biophysics of ASCR Brno, research scientist
• 2004-2006: Institute of Biophysics of ASCR Brno, young scientist
• 2001-2002: Faculty of Sciences MU Brno, Dpt. Of Microbiology, Principal Investigator of the grant project (part time employment)
• 2001-2003: Institute of Biophysics of ASCR Brno, Dept. of Molecular Cytology and Cytometry with High Resolution (PGS student + full time employment)
• 1997-2001: Faculty Hospital Brno, Dept. of Clinical Genetics, Laboratory of Molecular Genetics, research scientist

Teaching Activities

• Regular Teaching:
  
• 2007-now: F8270, Radiation Biophysics
• 2016-now: C9041 Structure and function of eukaryotic chromosomes
• 2016-now: XD100 Dissertation thesis supervision
• 2000-2001: Bi3061 Practicum from General Genetics
  Lectures given in the frame of other subjects:
  
• 2008-now: Bi8141, Molecular Physiology of the Genome
• 2008-2010: Bi7015, Chemical properties, structure and interactions of nucleic acids
  Further educational and popularization activities:
  
• Lecturer on the Sixth International Summer Student School on Nuclear Physics Methods and Accelerators in Biology and Medicine), Russian Academy of Sciences, Dubna, Russia, 2 - 12th July 2011 (in English, invited by Prof Dr. E.A. Krasavin and Assoc. Prof. Ing. Ivan Štekl, CsC.)
• IBP ASCR Seminars of the Research Groups
• Lecture at the CIC Biogune, Bilbao, Spain (invited by Dr. Luis Antonio Parada, PhD., that time The Cellular Biology and Stem Cells Unit of the Co-operative Bioscience Research Centre)
• Invited Lecture at the Brunel University of London (year 2011, invited by Dr. Rhona Anderson, PhD., Centre for Infection, Immunity and Disease Division of Biosciences Brunel University, Centre for Cell and Chromosome Biology)
• Lecture at the Palacky University Olomouc – The role of chromatin structure in DNA damage and repair, 2h, September 2012 (invited by Assoc. Prof. RNDr. Ondřej Vladan, Ph.D.)
  Supervisor of Graduation Theses
  
• Bc. Daniel Depeš, “Radiosensitizing effect of metal nanoparticles in tumor therapy”, Masaryk University, Faculty of Sciences, Brno, Diploma Thesis, 2016 (supervisor)
• Iva Falková, “Introduction of RNA fluorescence in situ hybridisation (RNA-FISH) for molecular-genetic diagnostics and research of the pathogenesis of myotonic dystrophy type I and II”, St. Elizabeth College of Health and Social Work in Bratislava, Dept. of Theoretical Disciplines, Laboratory Examination Methods and Dental Technology, Programme: Laboratory Examination Methods in Healthcare, Diploma thesis, 2009-2011 (supervisor-specialist)
• Mgr. Iva Falková, “Research on the roles of ribonuclear inclusions in molecular pathogenesis of myotonic dystrophy type I and II”. St. Elizabeth College of Health and Social Work in Bratislava, Dpt. of Theoretical Disciplines, Laboratory Examination Methods and Dental Technology, Programme: Laboratory Examination Methods in Healthcare, Rigorous thesis, 2011-2012 (supervisor-specialist)
• RNDr. Iva Falková, “The relationship between the higher-order chromatin structure, repair of DNA double strand breaks and mechanism of formation of chromosomal translocations relevant in carcinogenesis”, St. Elizabeth University of Healt and Social sciences, Bratislava, Disertation Thesis, 2012-2016 (supervisor-specialist)
• Mgr. Daniel Depeš, “Response of different cell types isolated from head and neck tumors to radiatiation damage of DNA”, Masaryk University, Faculty of Sciences, Brno, Disertation Thesis, from 2016 (supervisor)
• Ing. Lucie Ježková, “DNA damage and repair upon action of ionizing radiation with different linear energy transfr”, University of Chemistry and Technology Prague, Faculty of Food and Biochemical Technology, Department of Biochemistry and Microbiology, Disertation Thesis (supervisor-specialist)
• Zita Sotorníková, “The correlation between biochemical, genetic and pathological findings in foetuses indicated for abortion”, University of Pardubice, Institute of healthcare studies, Programme: Birth assistant, theoretical-practical, research bachelor thesis, 2001-2005, http://hdl.handle.net/10195/18574 (supervisor-specialist)
  Other Pedagogical Leadership:
  
• Lucie Dobešová, Mendel University, Brno, Faculty of Agronomy, Programme: Molecular Biology and Biotechnology, 19.6-30.6.2017, Bachelor practice (supervisor)
• Karina Blaženiaková, Mendel University, Brno, Faculty of Agronomy, Programme: Molecular Biology and Biotechnology, 18.7-29.7.2017, Bachelor practice (supervisor)
• Yuma Nagasaki, The Research Institute of Nuclear Engineering, University of Fukui, Tsuruga, Japan, November 2016, 1 week student visit (supervisor)
• Elena Baranova, Laboratory of Radiation Biology, Joint Institute for Nuclear Research/University Dubna, Dubna, Russia, one month student visit (May 2012) in the frame of her postgradual studies (supervisor)
• Ing. Lucie Ježkova, Institute of Chemical Technology Prague/JINR Dubna, one month student visit (September 2012) in the frame of her postgradual studies (supervisor)
• Mgr. Lenka Štefančíková, project OPVK - „Development of human resources in the field of cell biology, MŠMT OPVK CELLBIOL“ CZ.1.07/2.3.0030.0030, years 2012-2013 (supervisor)
• Mgr. Eva Pagáčová, Mentor in the project OPVK - „Development of human resources in the field of cell biology, MŠMT OPVK CELLBIOL“ CZ.1.07/2.3.0030.0030, years 2014-2015 (supervisor)
  List of Textbooks and Textbook Chapters:
  Havránková R. a kol. Clinical Radiobiology (Klinická radiobiologie). GRADA, Published 10. 01. 2020, catalog no.: 19052, ISBN: 978-80-247-4098-0. [in Czech]
• Clinical Radiobiology (in press; Chapter on the cell and chapter on the cell damage by ionizing radiation)
• Falk M., Lukasova E., Kozubek S. Repair mechanisms of DNA double-strand breaks – Biochemical and Spatio-Temporal Aspects, in Radiation Damage in Biomolecular Systems, Springer Science+Business Media (Eds.: G García, M Fuss), Dordrecht, Heidelberg, London, New York, 2012, p:329-359, ISSN 1618-7210, ISBN 978-94-007-2563-8, e-ISBN 978-94-007-2564-5, DOI 10.1007/978-94-007-2564-5_20
  List of Science Popularization Texts:
• Contributions to the Annual Research Reports of IBP ASCR in years 2006, 2007, 2008, 2009, 2010, 2011, 2012: Institute of Biophysics, Academy of Sciences of Czech Republic (2006-2012), Brno, Czech Republic
  List of Reviews and Educative Texts:
• Falk M. 2001. Myotonic Dystrophy and Trinucleotide Expansions. Inf. Papers of J.G. Mendel Society, 23: 24-41 (article in Czech)
• Lukáš Z., Kroupová I., Bednařík J., Falk M., Fajkusová L., Sedláčková J., Valášková I., Voháňka S. 2007. Muscular biopsy in myotonic dystrophy in the era of molecular genetics. Cesk Slov Neurol N. 70/103(4):395-401
• Falk M., Lukasova E. and Kozubek S. 2010. Higher order chromatin structure in DSB induction, repair and misrepair. Mut Res Rev 704(1-3):88-100, DOI 10.1016/j.mrrev.2010.01.013
  List of Educational Projects
  
• COST Action P9, Work Group 5, Radiation Damage in Biomolecular Systems, (European Cooperation in Science and Technology) (2004-2007) – successfully accomplished (M Falk as delegate of the Management Committee for Czech Rep.)
• COST NanoIBCT MP1002, Nano-Scale Insights into Ion Beam Cancer Therapy (European Cooperation in Science and Technology) (2011-2014) (M Falk as national delegate of the Management Committee for Czech Rep.)
• DNA double-strand break (DSB) repair and formation of chromosomal translocations in the context of higher-order chromatin structure and upon action of ionizing radiation of different quality. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2012/2014 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (from 2012). In process (Garants: A.E. Krasavin and M. Falk)
• Grant of the Government Plenipotentiary of CR, Chromatin structure modification and DNA repair pathways inhibition as tools to therapeutically increase or decrease cell survival upon the action of ionizing radiation of different quality (in the frame of the cooperation with JINR, theme number 04-9-1077-2012/2014 (from 2012). In process (Principal Investigators: A.E. Krasavin and M. Falk)
• Mentor in the project OPVK - „Development of human resources in the field of cell biology, CELLBIOL“ CZ.1.07/2.3.0030.0030, years 2012-(2015). In process.

Scientific and Research Activities

• Research Scopes and Interests:
  
• Radiobiology
  - radiation damage to the cell and chromatin upon the action of ionizing radiation of different qualities
  - biological effects of low doses of ionizing radiation, the process of carcinogenesis in general
  - formation and repair mechanisms of DNA double strand breaks (DSBs)
  - changes of higher-order chromatin structure at the sites of DSBs during the repair process
  - chromosomal translocations and the mechanisms of their formation
  - DSBs in carcinogenesis and, on the other hand, in tumour treatment
  - cell sensitization to effects of ionizing radiation, radioprotection
  - Ion-Beam Cancer Therapy, IBCT
  
• Molecular Biology
  - cell nucleus and its functional organisation
  - higher-order chromatin structure and its relationship with regulation of fundamental nuclear processes (transcription, DNA repair, replication)
  - epigenetics
  - chromatin dynamics and interactions
  - trinucleotide-repeat expansion diseases (TREDs)
  - new pathogenic mechanisms of leukaemia, especially acute promyelocytic leukaemia (APL)
  International and National Cooperation:
  
• European Institute of Oncology, Milan, Italy (Imaging Centre, IFOM-IEO Campus for Oncogenomics, prof. P.G. Pelicci, Dr. I. Dellino, Dr. Mario Faretta)
• Joint Institute for Nuclear Research (JINR), Russian Academy of Sciences, Dubna, Russia (Laboratory of Radiation Biology, Prof. E.A. Krasavin)
• Institute of Molecular Sciences, Orsay (ISMO)/University Paris Sud, Paris, France (The Biophysics and Biophotonic Group, Assoc. Prof. Sandrine Lacombe, Ph.D.)
• Kirchhoff-Institut für Physik, Heidelberg, Germany (Prof. Michael Hausmann)
• Penn State University College of Medicine, USA (Department of Biochemistry and Molecular Biology, Prof. Sergey Grigoryev)
• Faculty of Informatics, Masaryk University Brno, Czech Republic (Prof. Michal Kozubek, Dr. Pavel Matula, Dr. Petr Matula)
• Institute of Biochemistry and Experimental Oncology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic (Assoc. Prof. MUDr. Zdeněk Kleibl, Ph.D.)
• University of Defence Brno, Czech Republic (Department of Radiobiology, Faculty of Military Health Sciences, Hradec Králové, Prof. Jiřina Vávrová)
  
• Faculty Hospital Brno (Institute of Pathology, Prof. MUDr. Zdeněk Lukáš, CSc.)
  3 Most Important Publications
  
• Falk M., Lukasova E. and Kozubek S. 2010. Higher order chromatin structure in DSB induction, repair and misrepair. Mut Res Rev 704(1-3):88-100. DOI 10.1016/j.mrrev.2010.01.013, IF=7,1 (IF  5-years = 7.78)
• Falk M., Lukasova E, Kozubek S. 2008. Chromatin structure influences the sensitivity of DNA to γ-radiation. Biochim Biophys Acta MCR 1783(12):2398-2414. DOI: 10/1016/j.bbamcr.2008.07.010, IF=6,9
• Falk M., Lukasova E., Gabrielova B., Ondrej V., Kozubek S. 2007. Chromatin dynamics during DSB repair. Biochim Biophys Acta 1773(10):1534-45. IF=6,9
  3 Most Important Quotations
  
• Zink D., Fischer A.H., Nickerson J.A. 2004. Nuclear structure in cancer cells. Nature Reviews Cancer 4(9):677-687. IF 37.545
  (quoting the paper of Lukášová et al. 2004. Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium. Chromosoma 112(5):221-230)
• Roix J.J., McQueen P.G., Munson P.J., Parada L.A., Misteli T. 2003. Spatial proximity of translocation-prone gene loci in human lymphomas. Nature Genetics 34(3):287-291. IF 35.532
  (quoting the paper of Kozubek et al. 2002. 3D Structure of the human genome: Order in randomness. Chromosoma 111(5):321-331)
• Blank, M., Tang, Y., Yamashita, M., Burkett, S.S., Cheng, S.Y., Zhang, Y.E. 2012. A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nature Medicine 18(2):227-234. IF 22.5
  (quoting the paper of Falk et al. 2008. Chromatin structure influences the sensitivity of DNA to γ-radiation. Biochimica et Biophysica Acta - Molecular Cell Research 1783(12):2398-2414)
  
  over 50 articles, 6 book chapters, cumulative IF = 137.3, citations >744/ 721/ 853 (Scopus/ WOS/ ResearchGate), H-index = 15 (at 12.2019)
  Research Projects
  NATIONAL PROJECTS - M. Falk as Principal Investigator or Principal Co-Investigator
  
• 2019-2021 GAČR 19-09212S – Electrophilic fatty acids as important regulators of cell response irradiation, genomic instability and carcinogenesis
• 2016-2019 AZV (MZCR) 16-29835A – Molecular-genetic markers for prediction of radiotherapy response in head and neck cancer
• 2016-2018 Czech Science Foundation (GAČR) 16-12454S – Characterizing & modifying complex response of head & neck tumor cells to different radiations - a step forward to combined personalized radiotherapy
• 2012-2014 MEYS COST LD12039 – Influence of higher-order chromatin structure on the mechanism of DNA double-strand break (DSB) repair and formation of chromosomal translocations in cells irradiated with gamma rays and medically potentially relevant ion beams
• 2008-2011 IGA (MZCR): NS 9877-4/2008 – Expression of DMPK mRNA a DMPK protein in normal human tissues and presence of nuclear foci containing (CUG)n and (CCUG)n DMPK transcripts in tissues of myotonic dystrophy patients: the relationship with RNA-binding proteins (M. Falk – Co-Investigator)
• 2008-2011 GAAV IAA500040802 – New mechanisms of oncoprotein action in genesis of promyelocytic leukemia (in cooperation with European Institute of Oncology, Prof. P. G. Pelicci, Assoc. Prof. I. G. Dellino) (Accomplished without objections)
• 2006-2009 Czech Science Foundation (GAČR) 204/06/P349 – Dynamic structure a function of the cell nucleus associated with DNA breaks (Accomplished as “Excellent results with international importance”)
• GA202/02/1361, Interactions of metal ions with Dnase immobilized at magnetic carriers (2002-2004). Successfully defended – „Excellent results with International impact“. Research projects INTERNATIONAL, M Falk = Principal Investigator
  
• 2020 – 2023 DAAD-GAČR 20-04109J New Insights into cooperation of micro- and nano-scale elementary structural chromatin units in decision-making on DNA damage repair pathway (NANOREP). Principal investigator Martin Falk (CR), Michael Hausmann (Germany)
• 2017-2021 COST Action CA16113 – CliniMARK: 'good biomarker practice' to increase the number of clinically validated biomarkers
• 2017 – 2020 No: INTER-EXCELLENCE Project of the Ministry of Youth and Education CR (sub-programme: ‘INTER-ACTION’, LTAUSA: LTAUSA17160 – ‘Prevention and therapy of chronic inflammation diseases with nitrated fatty acids – PROTHECID’ (Prevence a terapie chronických zánětových onemocnění prostřednictvím nitrovaných mastných kyselin – PROTHECID)
• 2019 – 2020 DAAD-19-03 Projects of the Czech Academy of Sciences + DAAD ‘Nano-enhancers for future radiotherapy: New insights into the mechanism of nanoparticle-mediated tumor cell radiosensitization (NanoCancer)’ – Principal Investigator (CR): Falk Martin, Principal Investigator (Germany): Hausmann Michael (KIP, Heidelberg)
• 2019-2021 The 3-Plus-3 Project: Ionizing radiations of different quality and cell manipulations tools to eradicate radioresistant tumors. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2019/2020 „Ionizing radiations of different quality and cell manipulations as tool to eradicate radioresistant tumors“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2019 The Grant of Czech plenipotentiary: Effect of LET on DNA damage and complex response of normal and tumor cells to ionizing radiation - New insights into the mechanisms of radiation-induced repair foci (IRIF) formation at microscale and nanoscale. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2015/2020 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2016-2018 The 3-Plus-3 Project: Ionizing radiations of different quality and cell manipulations tools to eradicate radioresistant tumors. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2015/2017 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2018 The Grant of Czech plenipotentiary: Effect of RBE on DNA damage and complex cellular response to ionizing radiation - New insights into the mechanisms of formation of chromosomal translocations. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2015/2017 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2017 The Grant of Czech plenipotentiary: Effect of RBE on DNA damage and complex cellular response to ionizing radiation - New insights into the mechanisms of formation of chromosomal translocations. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2015/2017 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2016 The Grant of Czech plenipotentiary: Effect of RBE on DNA damage and complex cellular response to ionizing radiation - New insights into the mechanisms of formation of chromosomal translocations. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2015/2017 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2015 The 3-Plus-3 Project: Effect of RBE on DNA damage and complex cellular response to ionizing radiation - New insights into the mechanisms of formation of chromosomal translocations. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2015/2017 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2015 The Grant of Czech plenipotentiary: Chromatin structure modification and DNA repair pathways inhibition as tools to therapeutically increase or decrease cell survival upon the action of ionizing radiation of different quality. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2015/2017 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2014 The 3-Plus-3 Project: DNA double-strand break (DSB) repair and formation of chromosomal translocations in the context of higher-order chromatin structure and upon action of ionizing radiation of different quality. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2012/2014 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2014 The Grant of Czech plenipotentiary: Grant of the Government Plenipotentiary of CR, Chromatin structure modification and DNA repair pathways inhibition as tools to therapeutically increase or decrease cell survival upon the action of ionizing radiation of different quality (in the frame of the cooperation with JINR, theme number 04-9-1077-2012/2014 (Principal investigators: A.E. Krasavin and M. Falk)
• 2013 The 3-Plus-3 Project: Effect of RBE on DNA damage and complex cellular response to ionizing radiation - New insights into the mechanisms of formation of chromosomal translocations. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2012/2014 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2013 The Grant of Czech plenipotentiary: Grant of the Government Plenipotentiary of CR, Chromatin structure modification and DNA repair pathways inhibition as tools to therapeutically increase or decrease cell survival upon the action of ionizing radiation of different quality (in the frame of the cooperation with JINR, theme number 04-9-1077-2012/2014 (Principal investigators: A.E. Krasavin and M. Falk)
• 2012 The 3-Plus-3 Project: Effect of RBE on DNA damage and complex cellular response to ionizing radiation - New insights into the mechanisms of formation of chromosomal translocations. Project is included in Topical Plan for Research and International Cooperation in JINR in the frame of the theme number 04-9-1077-2012/2014 „Investigations of Induction and Repair Mechanisms After Action of Ionizing Radiation of Different Qualities“ (Principal investigators: A.E. Krasavin and M. Falk)
• 2012 The Grant of Czech plenipotentiary: Grant of the Government Plenipotentiary of CR, Chromatin structure modification and DNA repair pathways inhibition as tools to therapeutically increase or decrease cell survival upon the action of ionizing radiation of different quality (in the frame of the cooperation with JINR, theme number 04-9-1077-2012/2014 (Principal investigators: A.E. Krasavin and M. Falk)
• COST NanoIBCT MP1002, Nano-Scale Insights into Ion Beam Cancer Therapy, European project – European Cooperation in Science and Technology) (2010-2014). In process (M. Falk as national representative of CR in the Management Committee).
• COST Action P9, Work Group 5, Radiation Damage in Biomolecular Systems, (European project – European Cooperation in Science and Technology) (2004-2007). Successfully defended.
  - Some other Research Projects, including international (selection):
  
• GAAV: IBS5004010 – Development of new diagnostic tools for oncology (2000-2004)
• IGA MZ NC6987: Epigenetically controlled changes of gene expression in tumor diseases (2002-2004)
• GAČR GA202/02/0804: Estimation of the radiation risk for chronic myeloid leukemia development based on the distance measuring between ABL and BCR genes in hematopoietic cells (2002-2004)
• GAAV ČR IAA5004306: The structure of the human genome (2003-2007)
• GAČR GA202/04/0907: Live cell high-resolution microscopy (2004-2006)
• 6th EU Frame program LSHG-CT-2003-503441: 3D Genome structure and function (principal investigator Prof. Roel van Driel, Uni Amsterdam) (2004-2006)
• COST 405 (MŠMT 1P05OC084): Dynamic structure and function of the cell nucleus after irradiation. Accomplished as excellent (excellent results with international importance) (2005-2007)
• AVČR 1QS500040508: Histone H3 methylation in granulocytes as a prognostic marker of chronic myeloid leukemia remission (2005-2009)
• MŠMT LC535: Dynamics and organization of chromosomes during cell cycle in norm and pathology (2005-2009)
• GAČR P302/10/1022: Chromatin dynamics during DNA repair (2010-2015)
• MŠMT LC535: The Project of Excellence: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions (2012-2018)
• OPVK CZ.1.07: Development of human resources in the field of cell biology (2012-2015)
  

Internship and Research-Fellows

• 2002: Joint Institute for Nuclear Research (JINR), Russian Academy of Sciences, Dubna, Russia (Prof. E.A. Krasavin)
• 2008: The State Office for Nuclear Safety (SUJB), Brno, Czech Rep. – The preparing course and special state exam on special expert qualification in radiation protection (Radiation Protection Officer and Qualified Expert) at workplaces with important sources of ionizing radiation).
• 2008: Quantitative Real-Time PCR course organized by TATAA bio centre (Sweden) in Prague, Czech Rep.
• 2011: Brunel University London, Dpt. of Biomedical Sciences (Assoc. Prof. Rhona Anderson, Ph.D.), London, Great Britain
• 2011: Joint Institute for Nuclear Research, Russian Academy of Sciences, Dubna, Russia (Prof. Dr. E.A. Krasavin, Assoc. Prof. Ing. Ivan Štekl, CSc.)
• from 2016: Repeated visits to Kirchhoff Institut für Phisik, Heidelberg, Germany (with Prof. Michael Hausmann)

Membership

• Joint Program Committee of the Institute of Experimental Biology, Faculty of Science
  

Activities Outside University

• Secretary for Science (Board member) of Radiobiological Society for Crisis Planning of the Czech Medical Society of JE Purkyně
• Editorial Board of Scientific Reports (Nature)
• European Radiation Research Society (ERRS)
• Gregor Mendel Genetical Society (GSGM)
• Czech Microscopic Association
• Czech Society for Cell Biology
• CANAM (Center of Accelerators and Nuclear Analytical Methods) Committee Member
• Editorial Board of ISRN Genetics
• Editorial Board of International Journal of Radiology
• Editorial Board of Journal of Biochemistry and Biophysics
• Editorial Board of Frontiers in Physics
• Czech Republic national delegate in the European Cooperation in Science and Technology, project Nano-IBCT (2010-2014)
• COST (European Cooperation in Science and Technology) – National Delegate of the Czech Rep. in the Management Committee Nano-IBCT
• Scientific Selection Panel of the Center of Accelerators and Nuclear Analytical Methods (CANAM)
• Editorial Board of the International Scholarly Research Network (ISRN) Genetics

Awards from Scientific Community

• Awards from Scientific Community:
  
• 2018: 1st Prize for poster presentation given by The Society for Low Temperature Biology (SLTB) at the SLTB Meeting, 6th September 2018, Prague, Czech Republic (Contribution: Falk M. et al.. Complex description of cryopreserved cell nuclei defects by immunofluorescence microscopy: DNA lesions, chromatin decondensation, nuclear membrane ruptures).
• 2015: Young Investigators Travel Award, 15th International Congress of Radiation Research (ICRR 2015), Kyoto, Japan.
• 2009: The Premium of Otto Wichterle for outstanding young scientists, devoted by the Academy of Sciences of CR.
• 2008: Second place (not administrated) in the competition for the New England Biolabs Poster Prize, Biochemical Society Annual Symposium – DNA Damage: From Causes to Cures, December 15-17, 2008, Cambridge, Great Britain, for presented results: Direct visualization of DSB induction and repair in gene dense (RIDGE) and gene poor (anti-RIDGE) chromatin domains.
• 2008: The Prize of Deutsche Gesellchaft für DNA-Reparaturforschung (DGDR), 10th Biennial Meeting of the DGDR, Berlin, Germany: Devoted for results obtained at the field of DNA repair: “Different sensitivity and response of functionally distinct chromatin domains to DSB induction”
• 2004: The Prize of Institute of Biophysics of ASCR for excellent young scientists.
• Selected Invited Lectures:
  
• 1. Pelicci P.G., PML-RAR − A Model to Cure Leukemia. Salk Institute, Nature and IPSEN Foundation Conference on Biological Complexity: Diseases of Transcription. January 11-14, 2007, Salk Institute, La Jolla, CA, USA.
• 2. Falk M., Lukasova E., Kozubek S.: The role of higher-order chromatin structure and nuclear topography in DSB induction, repair and chromatin translocation. ESF-EMBO Symposium: Spatio-Temporal Radiation Biology: Transdisciplinary Advances for Biomedical Applications, 16-21 May 2009, Hotel Eden Roc, Sant Feliu de Guixols (Costa Brava), Spain
• 3. Falk M., Lukasova E., Bacikova A., Kozubek S.: The role of chromatin structure in DNA damage and its monitoring. ERR09 – Prague, 37th Annual Meeting of the European Radiation Research Society, 26-29th August 2009, Prague, Czech Republic.
• 4. Falk M., Lukášová E., Kozubek S., Štefančíková L. Higher-order chromatin structure in DNA double-strand break induction, repair and formation of chromosomal translocations. Brunel University (Invited by Dr. Rhona Anderson), June 29 - July 1, 2011, London, Great Britain.
• 5. Falk M., Lukášová E., Kozubek S., Štefančíková L. Higher-order chromatin structure in DNA double-strand break induction, repair and formation of chromosomal translocations. The ARR & UKEMS Joint Annual Meeting, June 29 - July 1, 2011, Nottingham University, Jubilee Campus, Nottingham, Great Britain.
• 6. Falk M., Lukášová E., Kozubek S., Štefančíková L., Weiterová L. Induction, repair and misrepair of DNA double-strand breaks (DSBs) in the context of higher-order chromatin structure. The 14th International Congress of Radiation Research, 28.08 - 01.09.2011, Warsaw, Poland.
• 7. Lukášová E., Kořistek Z., Klabusay M., Ondřej V., Grigoryev S., Bačíková A., Řezáčová M., Vávrová J., Kohútová V., (presented by) Falk M., Kozubek S. DNA damage and repair in the context of chromatin structure and function - the influence of cell differentiation and quality of ionizing radiation. 13th International Workshop on Radiation Damage to DNA, June 14-18, 2014, Massachusetts Institute of Technology (M.I.T.), Cambridge, MA, USA.
• 8. Štefančíková L., Lacombe S., Salado D., Porcel E., Pagáčová E., Tillement O., Lux F., Depeš D., Falková I., Bačíková A., Kozubek S., and Falk M (presenting author). The mechanism of metal nanoparticle-mediated radiosensitization of tumor cells may be independent of DNA damage amplification and DNA repair inhibition. 7th World Nano Conference, June 20-21, 2016, Cape Town, South Africa. (Falk M presenting author, Invited)
• 9. Falk M. Towards a complex view on DNA damage and repair – epigenetic and spatio-temporal aspects. 2nd International Conference on Systems and Synthetic Biology, August 18-20, 2016 London, UK. (Plenary Lecture, invited)
• 10. Falk M. Chromatin structure and chromosomal rearrangements in CD34+ cells and lymphocytes from Myelodysplastic syndromes (MDS) patients. 6th International Conference on Genomics & Pharmacogenomics September 12-14, 2016, Berlin, Germany. (Keynote lecture)
• 11. Falk M. Detection of DSB repair foci as a potent tool in biodosimetry and cancer research. Future Forces Forum (NATO), Medical Workshop, October 20, 2016, Prague, Czech Republic (invited).
• 12. Falk M et al. Tumor cell radiosensitization-ion beams and metal nanoparticles. 3rd International Conference on Systems and Synthetic Biology, July 20-21, 2017, Munich, Germany. (Keynote lecture)
• 13. Falk M et al. Metal nanoparticles in tumor cell radiosensitization. INTERNATIONAL CONFERENCE ON FUNCTIONAL NANOMATERIALS AND NANODEVICES, 24-27 September 2017, Budapest, Hungary
• 14. Falk M. Sensitive monitoring of DNA damage and repair in biodosimetry and cancer research. The Research Institute of Nuclear Engineering, University of Fukui, 15-23 March 2017, Tsuruga, Japan.
• 15. DNA damage and repair in normal and tumor cells upon cell exposure to ionizing radiation of different quality. BIT’s 8th Annual World Congress of Molecular & Cell Biology-2018, October 16-18, 2018, Fukuoka, Japan.
• 16. Falk M. Spatio-temporal aspects of DNA damage and repair upon action of ionizing radiations of different types (60 min Educational Lecture). World Congress on Medical Physics & Biomedical Engineering. June 3-8, 2018, Prague, Czech Republic. 60 min Invited lecture.
• 17. Falk M. Multiple mechanisms of metal nanoparticle-mediated radiosensitization of tumor cells? NANOSCIENCE MEET 2018: Annual conference on Nanoscience, Nanotechnology and Advanced materials. November 26-28, 2018, Bali, Indonesia. Invited lecture.

Major Publications

• KRATOCHVÍLOVÁ, Irena, O KOPEČNÁ, A BAČÍKOVÁ, E PAGÁČOVÁ, I FALKOVÁ, S E FOLLETT, K W Varga K ELLIOTT, M GOLAN a Martin FALK. Changes in Cryopreserved Cell Nuclei Serve as Indicators of Processes during Freezing andThawing. Langmuir. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2019, roč. 35, č. 23, s. 7496-7508. ISSN 0743-7463. Dostupné z: https://dx.doi.org/10.1021/acs.langmuir.8b02742. URL info
• HOFER, Michal, Z HOFEROVÁ a Martin FALK. Brief story on prostaglandins, inhibitors of their synthesis, hematopoiesis, and acute radiationsyndrome. Blood Cells, Molecules and Diseases. Orlando, Florida: Academic Press, 2019, roč. 24, č. 22, s. art. no. 4019. ISSN 1079-9796. Dostupné z: https://dx.doi.org/10.3390/molecules24224019. URL info
• JEZKOVA, L, M ZADNEPRIANETC, E KULIKOVA, E SMIRNOVA, T BULANOVA, Daniel DEPEŠ, Iva FALKOVÁ, A BOREYKO, E KRASAVIN, M DAVIDKOVA, Stanislav KOZUBEK, O VALENTOVA a Martin FALK. Particles with similar LET values generate DNA breaks of different complexity and reparability: a high-resolution microscopy analysis of gamma H2AX/53BP1 foci. NANOSCALE. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2018, roč. 10, č. 3, s. 1162-1179. ISSN 2040-3364. Dostupné z: https://dx.doi.org/10.1039/c7nr06829h. URL info
• FALK, Martin, I FALKOVÁ, O KOPEČNÁ, A BAČÍKOVÁ, E PAGÁČOVÁ, D ŠIMEK, M GOLAN, Stanislav KOZUBEK, M PEKAROVÁ, Follett SE, B KLEJDUS, Elliott KW, K VARGA, O TEPLÁ a I KRATOCHVÍLOVÁ. Chromatin architecture changes and DNA replication fork collapse are critical features in cryopreserved cells that are differentially controlled by cryoprotectants. Scientific reports. London: NATURE PUBLISHING GROUP, 2018, roč. 8, č. 1, s. Article number 14694. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-32939-5. URL info
• BOBKOVA, E, D DEPES, J-Ho LEE, L JEZKOVA, I FALKOVA, E PAGACOVA, O KOPECNA, M ZADNEPRIANETC, A BACIKOVA, E KULIKOVA, E SMIRNOVA, T BULANOVA, A BOREYKO, E KRASAVIN, F WENZ, F BESTVATER, G HILDENBRAND, M HAUSMANN a Martin FALK. Recruitment of 53BP1 proteins for DNA repair and persistence of repair clusters differ for cell typesas detected by single molecule localization microscopy. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2018, roč. 19, č. 12, s. art. no. 3713. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19123713. URL info
• DEPEŠ, Daniel, Jin-Ho LEE, Elizaveta BOBKOVA, Lucie JEZKOVA, Iva FALKOVA, Felix BESTVATER, Eva PAGACOVA, Olga KOPECNA, Mariia ZADNEPRIANETC, Alena BACIKOVA, Elena KULIKOVA, Elena SMIRNOVA, Tatiana BULANOVA, Alla BOREYKO, Evgeny KRASAVIN, Michael HAUSMANN a Martin FALK. Single-molecule localization microscopy as a promising tool for gamma H2AX/53BP1 foci exploration. The European Physical Journal D. New York: Springer, 2018, roč. 72, č. 9, s. 1-11. ISSN 1434-6060. Dostupné z: https://dx.doi.org/10.1140/epjd/e2018-90148-1. Full Text info
• HOFER, M, Z HOFEROVA, Daniel DEPEŠ a Martin FALK. Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review. Molecules. BASEL: Mayer und Muller, 2017, roč. 22, č. 5, 14 s. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules22050834. URL info
• HOFER, Michal, Z HOFEROVÁ a Martin FALK. Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines? International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2017, roč. 18, č. 7, s. art. no. 1385. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms18071385. URL info
• LUKÁŠOVÁ, Emilie, Aleš KOVAŘÍK, A BAČÍKOVÁ, Martin FALK a Stanislav KOZUBEK. Loss of lamin B receptor is necessary to induce cellular senescence. Biochemical Journal. 2017, roč. 474, č. 2, s. 281-300. ISSN 0264-6021. Dostupné z: https://dx.doi.org/10.1042/BCJ20160459. URL info
• KRATOCHVÍLOVÁ, I, M GOLAN, K POMEISL, J RICHTER, S SEDLÁKOVÁ, J ŠEBERA, J MIČOVÁ, Martin FALK, I FALKOVÁ, D ŘEHA, K W ELLIOTT, K VARGA, S E FOLLETT a D ŠIMEK. Theoretical and experimental study of the antifreeze protein AFP752, trehalose and dimethylsulfoxide cryoprotection mechanism: correlation with cryopreserved cell viability. RSC Advances. Cambridge: Royal Society of Chemistry, 2017, roč. 7, č. 1, s. 352-360. ISSN 2046-2069. Dostupné z: https://dx.doi.org/10.1039/c6ra25095e. URL info
• HOFER, Michal, Martin FALK, Denisa KOMŮRKOVÁ, Iva FALKOVÁ, Alena BAČÍKOVÁ, Bořivoj KLEJDUS, Eva PAGÁČOVÁ, Lenka ŠTEFANČÍKOVÁ, Lenka WEITEROVÁ, Karel J. ANGELIS, Stanislav KOZUBEK, Ladislav DUŠEK a Štefan GALBAVÝ. Two New Faces of Amifostine: Protector from DNA Damage in Normal Cells and Inhibitor of DNA Repair in Cancer Cells. Journal of Medicinal Chemistry. Washington: American Chemical Society, 2016, roč. 59, č. 7, s. 3003-3017. ISSN 0022-2623. Dostupné z: https://dx.doi.org/10.1021/acs.jmedchem.5b01628. info
• ŠTEFANČÍKOVÁ, Lenka, S LACOMBE, D SALADO, E PORCEL, Eva PAGÁČOVÁ, O TILLEMENT, François LUX, Daniel DEPEŠ, Stanislav KOZUBEK a Martin FALK. Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells. JOURNAL OF NANOBIOTECHNOLOGY. LONDON: BIOMED CENTRAL LTD, 2016, roč. 14, 15 s. ISSN 1477-3155. Dostupné z: https://dx.doi.org/10.1186/s12951-016-0215-8. URL info
• FALK, Martin, Emilie LUKÁŠOVÁ, Lenka ŠTEFANČÍKOVÁ, E BARANOVÁ, I FALKOVÁ, L JEŽKOVÁ, M Bačíková A DAVÍDKOVÁ, J VACHELOVÁ, A MICHAELIDESOVÁ a Stanislav KOZUBEK. Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure. Applied Radiation and Isotopes. Elsevier, 2014, roč. 83, s. 177-185. ISSN 0969-8043. Dostupné z: https://dx.doi.org/10.1016/j.apradiso.2013.01.029. info
• JEŽKOVÁ, L, Martin FALK, I FALKOVÁ, M DAVÍDKOVÁ, A BAČÍKOVÁ, Lenka ŠTEFANČÍKOVÁ, J Michaelidesová A VACHELOVÁ, Emilie LUKÁŠOVÁ, A BOREYKO, E KRASAVIN a Stanislav KOZUBEK. Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays andprotons in action. Applied Radiation and Isotopes. Elsevier, 2014, roč. 83, s. 128-136. ISSN 0969-8043. Dostupné z: https://dx.doi.org/10.1016/j.apradiso.2013.01.022. info
• SEVCIK, J, Martin FALK, L MACUREK, P KLEIBLOVA, F LHOTA, J HOJNY, L STEFANCIKOVA, M Bartek J JANATOVA, J STRIBRNA, Z HODNY, L JEZKOVA, P POHLREICH a Z KLEIBL. Expression of human BRCA1δ17-19 alternative splicing variant with a truncated BRCT domain inMCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damageresponse. Cellular Signalling. Elsevier Science, 2013, roč. 25, č. 5, s. 1186-1193. ISSN 0898-6568. Dostupné z: https://dx.doi.org/10.1016/j.cellsig.2013.02.008. info
• LUKÁŠOVÁ, E, Zdeněk KOŘÍSTEK, M KLABUSAY, Vladan ONDŘEJ, S GRIGORYEV, A BAČÍKOVÁ, M ŘEZÁČOVÁ, Martin FALK, J VÁVROVÁ, V KOHÚTOVÁ a Stanislav KOZUBEK. Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damageresponse; these properties are absent in immature AML granulocytes. Biochimica et biophysica acta : Molecular Cell Research. Amsterdam: Elsevier, 2013, roč. 1833, č. 3, s. 767-779. ISSN 0167-4889. Dostupné z: https://dx.doi.org/10.1016/j.bbamcr.2012.12.012. info
• SEVCIK, J, Martin FALK, P KLEIBLOVA, Filip LHOTA, Lenka ŠTEFANČÍKOVÁ, Martina JANÁTOVÁ, Lenka WEITEROVÁ, Emilie LUKÁŠOVÁ, Stanislav KOZUBEK, Petr POHLREICH a Zdeněk KLEIBL. The BRCA1 alternative splicing variant delta14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells. Cellular Signalling. 2012, 24 (5), s. 1023-1030. ISSN 0898-6568. URL info
• LUKÁŠ, Zdeněk, Martin FALK, Josef FEIT, Ondřej SOUČEK, Iva FALKOVÁ, Lenka ŠTEFANČÍKOVÁ, Eva JANOUŠOVÁ, Lenka FAJKUSOVÁ, Jana ZAORÁLKOVÁ a Renata HRABÁLKOVÁ. Sequestration of MBNL1 in tissues of patients with myotonic dystrophy type 2. Neuromuscular Disorders. London: Elsevier, 2012, roč. 22, č. 7, s. 604-616. ISSN 0960-8966. Dostupné z: https://dx.doi.org/10.1016/j.nmd.2012.03.004. URL info
• FALK, Martin, Emilie LUKÁŠOVÁ a Stanislav KOZUBEK. Repair mechanisms of DNA double-strand breaks – Biochemical and Spatio-Temporal Aspects. In Radiation Damage in Biomolecular Systems. Dordrecht, Heidelberg, London, New York: Springer Science+Business Media, 2012, s. 329-359. Dostupné z: https://dx.doi.org/10.1007/978-94-007-2564-5_20. info
• FALK, Martin, E LUKÁŠOVÁ, Lenka ŠTEFANČÍKOVÁ, Lenka WEITEROVÁ, A BAČÍKOVÁ a Stanislav KOZUBEK. Function of Chromatin Structure and Dynamics in DNA Damage, Repair and Misrepair; in press. In Book of Proceedings, American Institute of Physics [AIP]. 2012. info
• SOUČEK, Ondřej, Stanislav VOHÁŇKA, Jana ZAORÁLKOVÁ, Iva FALKOVÁ, Renata HRABÁLKOVÁ, M. FALK a Zdeněk LUKÁŠ. Sequestration of MBNL1 Protein by Mutant ZNF9 mRNA in Lymphocytes of Patients with Myotonic Dystrophy Type 2. Česká a Slovenská neurologie a neurochirurgie. Praha: Česká lékařská společnost J.E.Purkyně, 2012, roč. 75, č. 5, s. 606-609. ISSN 1210-7859. info
• ŠEVČÍK, Jan, Filip LHOTA, Petra KLEIBLOVÁ, Jan HOJNÝ, Martin FALK, Lenka ŠTEFANČÍKOVÁ, O MĚŠŤÁK, D PAVLIŠTA, P POHLREICH a Zdeněk KLEIBL. Alternative splicing of BRCA1 - desired tool for DNA repair regulation or “messy garbage” of splicing events? In Genes, Genetics & Genomics 2012 (G3 2012), May 10th-11th, 2012, the First Faculty of Medicine, Charles University, Prague, Czech RepublicIn: Book of Abstracts (další údaje nedostupné). 2012. info
• FALK, Martin, Emilie LUKÁŠOVÁ a Stanislav KOZUBEK. Higher-order chromatin structure in DSB induction, repair and misrepair. Mutation Research - Reviews in Mutation Research. 2010, 704 (1-3), s. 88-100. URL info
• FALK, Martin, Emilie LUKÁŠOVÁ a Stanislav KOZUBEK. Chromatin structure influences the sensitivity of DNA to gamma-radiation. Biochimica et biophysica acta : Molecular Cell Research. Amsterdam: Elsevier, 2008, roč. 1783, č. 12, s. 2398-2414. ISSN 0167-4889. Dostupné z: https://dx.doi.org/10.1016/j.bbamcr.2008.07.010. info
• FALK, Martin, Emilie LUKÁŠOVÁ, Barbora GABRIELOVÁ, Vladan ONDŘEJ a Stanislav KOZUBEK. Chromatin dynamics during DSB repair. Biochimica et Biophysica Acta, Molecular Cell Research. Amsterdam: Elsevier, 2007, roč. 1773, č. 10, s. 1534-1545. ISSN 0167-4889. info
• PELICCI, P G. PML-RAR − A Model to Cure Leukemia. In Salk Institute, Nature and Foundation IPSEN Conference on Biological Complexity: Diseases of Transcription. 11. – 14. ledna, 2007, Salk Institute, La Jolla, CA, USA (Invited Lecture). 2007. info
• FALK, Martin, Emilie LUKÁŠOVÁ, Barbora GABRIELOVÁ, Iva KROUPOVÁ a Stanislav KOZUBEK. Nuclear Organization and Dynamics of the DSB-repair: Direct Visualization of Double Strand Breaks in Functionally Different Chromatin Domains. In Salk Institute, Nature and Fondation IPSEN Conference on Biological Complexity: Diseases of Transcription, 11. – 14. ledna, 2007, Salk Institute, La Jolla, Kalifornie, USA.In: Book of Abstracts, p. 46. 2007. info
• ONDŘEJ, Vladan, Stanislav KOZUBEK, Emilie LUKÁŠOVÁ, Martin FALK, Pavel MATULA, Petr MATULA a Michal KOZUBEK. Directional motion of foreign plasmid DNA to nuclear HP1 foci. Chromosome Research. Dordrecht: Springer, 2006, roč. 14, č. 5, s. 505-514. ISSN 0967-3849. info
• LUKÁŠOVÁ, Emilie, Zdeněk KOŘÍSTEK, Martin FALK, Stanislav KOZUBEK, Sergei GRIGORYEV, Michal KOZUBEK, Vladan ONDŘEJ a Iva KROUPOVÁ. Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities. Journal of Leukocyte Biology. New York: Society for Leukocyte Biology, 2005, roč. 77, č. 1, s. 100-111. ISSN 0741-5400. info
• LUKÁŠOVÁ, Emilie, Stanislav KOZUBEK, Martin FALK, Michal KOZUBEK, Jan ŽALOUDÍK, Václav VAGUNDA a Zdeněk PAVLOVSKÝ. Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium. Chromosoma. Berlin: Springer-Verlag, 2004, roč. 112, č. 5, s. 221-230. ISSN 0009-5915. info
• FALK, Martin, Urshula FROSTER a Marie VOJTÍŠKOVÁ. Metodické možnosti stanovení počtu CTG/CAG opakování v trinukleotidových repeticích lidského genomu. Časopis lékařů českých. Czech republic: Česká lékařská společnost JEP Praha, 2003, roč. 142, č. 10, s. 513-518. info
• KOZUBEK, Stanislav, Emilie LUKÁŠOVÁ, Pavla JIRSOVÁ, Irena KOUTNÁ, Michal KOZUBEK, Alena GAŇOVÁ, Eva BÁRTOVÁ, Martin FALK a Renata TASLEROVÁ. 3D Structure of the human genome: Order in randomness. Chromosoma. Berlin: Springer-Verlag, 2002, roč. 111, č. 5, s. 321-331. ISSN 0009-5915. info
• FALK, Martin, Emilie LUKÁŠOVÁ, Stanislav KOZUBEK a Michal KOZUBEK. Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes. Gene. Amsterdam: Elsevier, 2002, roč. 292, č. 1, s. 13-24. ISSN 0378-1119. info
• LUKÁŠOVÁ, Emilie, Stanislav KOZUBEK, Michal KOZUBEK, Martin FALK a Jana AMRICHOVÁ. The 3D structure of human chromosomes in cell nuclei. Chromosome Research. Dordrecht: Kluwer Academic, 2002, roč. 10, č. 7, s. 535-548. ISSN 0967-3849. info

2019/12/19