Project information
Molekulární diagnostika hypodoncie a možnosti zubních autotransplantací
- Project Identification
- NT11420-6/2010
- Project Period
- 9/2010 - 12/2015
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- MU Faculty or unit
- Faculty of Science
- Keywords
- Oligodontia; gene mutation; DNA; sequencing; polymorphism; autotransplantation; immunohistochemistry
- Cooperating Organization
-
Institute of Animal Physiology and Genetics of thr ASCR, v. v. i.
St. Anne's University Hospital Brno
- Responsible person prof. MUDr. Jiří Vaněk, CSc.
Předmět a metodika řešení projektu jsou následující: 1) Vytvoření souborů pacientů s hypodoncií detekovanou na základě RTG resp. CT vyšetření; 2) screening vzorků na mutace v genech PAX9, MSX1, AXIN2 a dalších relevantních genů metodou kapilárního sekvenování – analýza prevalence mutací; 3) analýza tkání po autotransplantacích (molekulární a buněčná analýza komplexu zub-kost-periodont).
Publications
Total number of publications: 28
2022
-
WNT10A variants: following the pattern of inheritance in tooth agenesis and self-reported family history of cancer
Clinical Oral Investigations, year: 2022, volume: 26, edition: 12, DOI
2019
-
Next generation sequencing reveals a novel nonsense mutation in MSX1 gene related to oligodontia
Year: 2019, type: Appeared in Conference without Proceedings
2018
-
Next generation sequencing reveals a novel nonsense mutation in MSX1 gene related to oligodontia
PLOS ONE, year: 2018, volume: 13, edition: 9, DOI
2017
-
Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review
Neuroendocrinology Letters, year: 2017, volume: 38, edition: 3
-
PAX9 gene mutations and tooth agenesis: A review
Clinical Genetics, year: 2017, volume: 92, edition: 5, DOI
2016
-
Mikroskopická analýza transplantovaných zubů u hlodavců
Ortodoncie, year: 2016, volume: 25, edition: 1
-
Polymorphisms in Vitamin D Receptor Gene in Orthodontic Patients with External Apical Root Resorption
Year: 2016, type: Appeared in Conference without Proceedings
2015
-
A screen of a large Czech cohort of oligodontia patients implicates a novel mutation in the PAX9 gene
EUROPEAN JOURNAL OF ORAL SCIENCES, year: 2015, volume: 123, edition: 2, DOI
-
Novel PAX9 gene mutation in Czech monozygotic twins with oligodontia
Year: 2015, type: Conference abstract
-
Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population
Neuroendocrinology Letters, year: 2015, volume: 36, edition: 5