Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 361
2011
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Human embryonic stem cells suffer from centrosomal amplification
Stem Cells, year: 2011, volume: 29, edition: 1, DOI
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Characterization of resistance of human embryonic stem cells and neural precursor cells to mechanisms of activation of programmed cell death induced by death receptors
Year: 2011, type: Conference abstract
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Identification of minor proportion p53 mutations selected later by therapy
Year: 2011, type: Conference abstract
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Interactions with bone marrow stromal cells protect lymphoma B-cells from rituximab induced apoptosis and inhibition of integrin alfa-4-beta-1 (VLA4) can overcome this resistency
Year: 2011, type: Conference abstract
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Komplex CDK2/Cyklin B a jeho možná úloha v lidských embryonálních kmenových buňkách
Year: 2011, type: Conference abstract
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Léčebná studie Relapsed AML 2001/01, 02 pro děti s relapsem akutní myeloidní leukemie nebo primárně rezistentní nemocí zlepšila jejich nadeji na vyléčení.
Transfuze a hematologie dnes, year: 2011, volume: 17, edition: 3
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Long-term results of allogeneic hematopoietic stem cell transplantation after reduced-intensity conditioning with busulfan, fludarabine, and antithymocyte globulin
Neoplasma, year: 2011, volume: 58, edition: 5, DOI
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Lymfoproliferativní onemocnění u pacientů s autoimunitními a infekčními onemocněními: význam antigenní stimulace a zánětlivých procesů
Časopis Lékařů Českých, year: 2011, volume: 150, edition: 3
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MicroRNA mutational analysis in patients with chronic lymphocytic leukemia
Year: 2011, type: Conference abstract
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MicroRNA-650 expression is coupled with the regulation of immunoglobulin lambda light chain in chronic lymphocytic leukemia
Year: 2011, type: Conference abstract