The overall objective of 4DPD-Omics is to perform a spatiotemporal analysis of gene and protein expression changes to determine whether specific cellular processes implicated in α-Syn pathology act in a cell type- or disease stage-dependent manner, and to identify novel cell-specific targets and strategies for drug development. Through aligned cell-type specific analysis of rodent models and human tissue, we will elucidate common and distinct mechanisms to optimize translation of findings from pre-clinical studies into the clinic. Comparing and interrogating results obtained from in vivo models and human Braak stage 0-VI post mortem tissues will also generate important data for the community regarding the suitability of animal and human post mortem studies for neurodegeneration research.